Clinical outcome in 520 consecutive Danish rectal cancer patients treated with short course preoperative radiotherapy

Preoperative short-course radiotherapy in rectal cancer patients: results and prognostic factors

Objective The purpose of this study was to evaluate the clinical outcome of preoperative short-course radiotherapy for rectal cancer patients. Methods The study group comprised 210 patients with pathologically proven resectable rectal cancer. Between 2001 and 2013, they were treated preoperatively with short-course radiotherapy (25 Gy delivered in five fractions), followed by total mesorectal...

Clinical results and toxicity for short-course preoperative radiotherapy and total mesorectal excision in rectal cancer patients

Short-course preoperative radiotherapy (SCPRT) is an alternative method to chemoirradiation for patients with Stage II and III rectal cancer when no downsizing is needed, but there is still widespread reluctance to use this method because of fear of side effects from high-fraction doses. This paper reports on a single institution patient cohort of operated rectal cancer patients after SCPRT, ev...

Preoperative radiotherapy "short course" in rectal cancer in elder patient: low impact on tumor regression

Preoperative radiotherapy of locally advanced rectal cancer: clinical outcome of short-course and long-course treatment with or without concomitant chemotherapy.

BACKGROUND Preoperative radiotherapy is considered to be standard treatment for locally advanced rectal cancer. The timing and dosage of radiotherapy with or without preoperative chemotherapy remain controversial issues. The objective of this study was to evaluate relevant clinical outcomes of two preoperative radiotherapy regimens - the short-course and -long-course radiotherapy with or withou...

Does preoperative radiotherapy improve outcome in patients with resectable rectal cancer?

Design: Multicentre international randomised controlled trial. Setting: 108 hospitals, with a predominance of hospitals in Holland. Patients: 1805 eligible patients with histologically proven adenocarcinoma of the rectum. Patients with fixed tumours were excluded. All patients had either a low anterior resection or an abdominoperineal resection using the standardised surgical approach of total ...